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1

Structure-Based Discovery of Natural-Product-like TNF-α Inhibitors

Daniel Shiu-Hin Chan, Ho-Man Lee, Fang Yang, Chi-Ming Che, Catherine C. L. Wong, Ruben Abagyan, Chung-Hang Leung, Dik-Lung Ma

Journal:

Angewandte Chemie

Year:

2010

Language:

english

File:

PDF, 870 KB

english, 2010

2

DNA-Binding Small Molecules as Inhibitors of Transcription Factors

Chung-Hang Leung, Daniel Shiu-Hin Chan, Victor Pui-Yan Ma, Dik-Lung Ma

Journal:

Medicinal Research Reviews

Year:

2012

Language:

english

File:

PDF, 741 KB

english, 2012

3

Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer

Daniel Shiu-Hin Chan, Hui Yang, Maria Hiu-Tung Kwan, Zhen Cheng, Paul Lee, Li-Ping Bai, Zhi-Hong Jiang, Chun-Yuen Wong, Wang-Fun Fong, Chung-Hang Leung, Dik-Lung Ma

Journal:

Year:

2011

Language:

english

File:

PDF, 1.18 MB

english, 2011

4

Molecular modeling of drug–DNA interactions: Virtual screening to structure-based design

Dik-Lung Ma, Daniel Shiu-Hin Chan, Paul Lee, Maria Hiu-Tung Kwan, Chung-Hang Leung

Journal:

Year:

2011

Language:

english

File:

PDF, 1.73 MB

english, 2011

5

Recent advances in luminescent heavy metal complexes for sensing

Dik-Lung Ma, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Ka-Ho Leung, Hong-Zhang He, Chung-Hang Leung

Journal:

Coordination Chemistry Reviews

Year:

2012

Language:

english

File:

PDF, 3.11 MB

english, 2012

6

Bioactive Luminescent Transition-Metal Complexes for Biomedical Applications

Ma, Dik-Lung, He, Hong-Zhang, Leung, Ka-Ho, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Angewandte Chemie International Edition

Year:

2013

Language:

english

File:

PDF, 2.54 MB

english, 2013

7

Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex

Lu, Lihua, He, Hong-Zhang, Zhong, Hai-Jing, Liu, Li-Juan, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Sensors and Actuators B: Chemical

Year:

2014

Language:

english

File:

PDF, 393 KB

english, 2014

8

Visualization of Zn 2+ Ions in Live Zebrafish Using a Luminescent Iridium(III) Chemosensor

Ma, Dik-Lung, He, Hong-Zhang, Zhong, Hai-Jing, Lin, Sheng, Chan, Daniel Shiu-Hin, Wang, Liang, Lee, Simon Ming-Yuen, Leung, Chung-Hang, Wong, Chun-Yuen

Journal:

ACS Applied Materials & Interfaces

Year:

2014

Language:

english

File:

PDF, 3.86 MB

english, 2014

9

Mass spectrometry for fragment screening

Chan, Daniel Shiu-Hin, Whitehouse, Andrew J., Coyne, Anthony G., Abell, Chris

Journal:

Essays in Biochemistry

Year:

2017

Language:

english

File:

PDF, 803 KB

english, 2017

10

Structure-Based Discovery of Natural-Product-like TNF-α Inhibitors

Daniel Shiu-Hin Chan, Ho-Man Lee, Fang Yang, Chi-Ming Che, Catherine C. L. Wong, Ruben Abagyan, Chung-Hang Leung, Dik-Lung Ma

Journal:

Angewandte Chemie International Edition

Year:

2010

Language:

english

File:

PDF, 870 KB

english, 2010

11

ChemInform Abstract: An Efficient Synthesis of Brominated 4-Alkyl-2(5H)-furanones.

George Iskander, Ruonan Zhang, Daniel Shiu-Hin Chan, David StC. Black, Mahiuddin Alamgir, Naresh Kumar

Journal:

Year:

2009

File:

PDF, 39 KB

2009

12

ChemInform Abstract: Synthesis of Some New Biheterocycles by a One-Pot Suzuki—Miyaura Coupling Reaction

Mandar Deodhar, David StC. Black, Daniel Shiu-Hin Chan, Naresh Kumar

Journal:

Year:

2010

File:

PDF, 30 KB

2010

13

ChemInform Abstract: Identification of Natural Product Fonsecin B as a Stabilizing Ligand of c-myc G-Quadruplex DNA by High-Throughput Virtual Screening.

Ho-Man Lee, Daniel Shiu-Hin Chan, Fang Yang, Ho-Yu Lam, Siu-Cheong Yan, Chi-Ming Che, Dik-Lung Ma, Chung-Hang Leung

Journal:

Year:

2010

File:

PDF, 16 KB

2010

14

ChemInform Abstract: Oligonucleotide-Based Luminescent Detection of Metal Ions.

Dik-Lung Ma, Daniel Shiu-Hin Chan, Bradley Yat-Wah Man, Chung-Hang Leung

Journal:

Year:

2011

File:

PDF, 18 KB

2011

15

Structure-Based Repurposing of FDA-Approved Drugs as TNF-α Inhibitors

Dr. Chung-Hang Leung, Daniel Shiu-Hin Chan, Maria Hiu-Tung Kwan, Zhen Cheng, Chun-Yuen Wong, Guo-Yuan Zhu, Wang-Fun Fong, Dr. Dik-Lung Ma

Journal:

Year:

2011

Language:

english

File:

PDF, 514 KB

english, 2011

16

An efficient synthesis of brominated 4-alkyl-2(5H)-furanones

George Iskander, Ruonan Zhang, Daniel Shiu-Hin Chan, David StC Black, Mahiuddin Alamgir, Naresh Kumar

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 458 KB

english, 2009

17

A Metal-Based Inhibitor of Tumor Necrosis Factor-α

Dr. Chung-Hang Leung, Hai-Jing Zhong, Hui Yang, Zhen Cheng, Daniel Shiu-Hin Chan, Victor Pui-Yan Ma, Prof. Ruben Abagyan, Dr. Chun-Yuen Wong, Dr. Dik-Lung Ma

Journal:

Angewandte Chemie

Year:

2012

Language:

english

File:

PDF, 1.07 MB

english, 2012

18

A Metal-Based Inhibitor of Tumor Necrosis Factor-α

Dr. Chung-Hang Leung, Hai-Jing Zhong, Hui Yang, Zhen Cheng, Daniel Shiu-Hin Chan, Victor Pui-Yan Ma, Prof. Ruben Abagyan, Dr. Chun-Yuen Wong, Dr. Dik-Lung Ma

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 1.08 MB

english, 2012

19

Oligonucleotide-Based Luminescent Detection of Metal Ions

Dr. Dik-Lung Ma, Daniel Shiu-Hin Chan, Dr. Bradley Yat-Wah Man, Dr. Chung-Hang Leung

Journal:

Chemistry – An Asian Journal

Year:

2011

Language:

english

File:

PDF, 1.41 MB

english, 2011

20

Identification of natural product Fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening

Lee, Ho-Man, Chan, Daniel Shiu-Hin, Yang, Fang, Lam, Ho-Yu, Yan, Siu-Cheong, Che, Chi-Ming, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 1.04 MB

english, 2010

21

Label-free sensing of pH and silver nanoparticles using an “OR” logic gate

Dik-Lung Ma, Hong-Zhang He, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Ka-Ho Leung, Hai-Jing Zhong, Lihua Lu, Jean-Louis Mergny, Chung-Hang Leung

Journal:

Analytica Chimica Acta

Year:

2012

Language:

english

File:

PDF, 592 KB

english, 2012

22

Drug repositioning by structure-based virtual screening

Ma, Dik-Lung, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Chemical Society Reviews

Year:

2013

Language:

english

File:

PDF, 2.05 MB

english, 2013

23

In silico screening of quadruplex-binding ligands

Dik-Lung Ma, Victor Pui-Yan Ma, Daniel Shiu-Hin Chan, Ka-Ho Leung, Hai-Jing Zhong, Chung-Hang Leung

Journal:

Year:

2012

Language:

english

File:

PDF, 605 KB

english, 2012

24

Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening

Zhong, Hai-Jing, Pui-Yan Ma, Victor, Cheng, Zhen, Shiu-Hin Chan, Daniel, He, Hong-Zhang, Leung, Ka-Ho, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2012

Language:

english

File:

PDF, 432 KB

english, 2012

25

Label-free detection of sub-nanomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe

Hong-Zhang He, Ka-Ho Leung, Hui Yang, Daniel Shiu-Hin Chan, Chung-Hang Leung, Jun Zhou, Anne Bourdoncle, Jean-Louis Mergny, Dik-Lung Ma

Journal:

Biosensors and Bioelectronics

Year:

2013

Language:

english

File:

PDF, 365 KB

english, 2013

26

Label-free luminescent oligonucleotide-based probes

Ma, Dik-Lung, He, Hong-Zhang, Leung, Ka-Ho, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Chemical Society Reviews

Year:

2013

Language:

english

File:

PDF, 3.14 MB

english, 2013

27

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion

He, Hong-Zhang, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Chemical Communications

Year:

2012

Language:

english

File:

PDF, 2.54 MB

english, 2012

28

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

Leung, Chung-Hang, Yang, Hui, Ma, Victor Pui-Yan, Chan, Daniel Shiu-Hin, Zhong, Hai-Jing, Li, Ying-Wei, Fong, Wang-Fun, Ma, Dik-Lung

Journal:

Year:

2012

Language:

english

File:

PDF, 188 KB

english, 2012

29

A label-free G-quadruplex-based switch-on fluorescence assay for the selective detection of ATP

He, Hong-Zhang, Pui-Yan Ma, Victor, Leung, Ka-Ho, Shiu-Hin Chan, Daniel, Yang, Hui, Cheng, Zhen, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

The Analyst (Royal Society of Chemistry)

Year:

2012

Language:

english

File:

PDF, 188 KB

english, 2012

30

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar strontium(ii) ions in sea water

Leung, Ka-Ho, Ma, Victor Pui-Yan, He, Hong-Zhang, Chan, Daniel Shiu-Hin, Yang, Hui, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Year:

2012

Language:

english

File:

PDF, 474 KB

english, 2012

31

Simple DNA-based logic gates responding to biomolecules and metal ions

Ma, Dik-Lung, He, Hong-Zhang, Chan, Daniel Shiu-Hin, Leung, Chung-Hang

Journal:

Chemical Science

Year:

2013

Language:

english

File:

PDF, 1.44 MB

english, 2013

32

Simple and Convenient G-Quadruplex-Based Turn-On Fluorescence Assay for 3′ → 5′ Exonuclease Activity

Leung, Chung-Hang, Chan, Daniel Shiu-Hin, Man, Bradley Yat-Wah, Wang, Chuan-Jen, Lam, Wing, Cheng, Yung-Chi, Fong, Wang-Fun, Hsiao, Wen-Luan Wendy, Ma, Dik-Lung

Journal:

Analytical Chemistry

Year:

2011

Language:

english

File:

PDF, 408 KB

english, 2011

33

A selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar silver(i) ions in aqueous solution

Man, Bradley Yat-Wah, Chan, Daniel Shiu-Hin, Yang, Hui, Ang, Si-Wo, Yang, Fang, Yan, Siu-Cheong, Ho, Chi-Ming, Wu, Peng, Che, Chi-Ming, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 1.93 MB

english, 2010

34

Structure-based design of flavone derivatives as c-myc oncogene down-regulators

Yang, Hui, Zhong, Hai-Jing, Leung, Ka-Ho, Chan, Daniel Shiu-Hin, Ma, Victor Pui-Yan, Fu, Wai-Chung, Nanjunda, Rupesh, Wilson, W. David, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

European Journal of Pharmaceutical Sciences

Year:

2013

Language:

english

File:

PDF, 3.03 MB

english, 2013

35

Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe

Leung, Ka-Ho, He, Hong-Zhang, Ma, Victor Pui-Yan, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Zhou, Jun, Mergny, Jean-Louis, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Chemical Communications

Year:

2013

Language:

english

File:

PDF, 1.74 MB

english, 2013

36

Luminescent oligonucleotide-based detection of enzymes involved with DNA repair

Leung, Chung-Hang, Zhong, Hai-Jing, He, Hong-Zhang, Lu, Lihua, Chan, Daniel Shiu-Hin, Ma, Dik-Lung

Journal:

Chemical Science

Year:

2013

Language:

english

File:

PDF, 1.33 MB

english, 2013

37

Hit identification of IKKβ natural product inhibitor

Chung-Hang Leung, Daniel Shiu-Hin Chan, Ying-Wei Li…

Journal:

BMC Pharmacology and Toxicology

Year:

2013

Language:

english

File:

PDF, 526 KB

english, 2013

38

Metal complexes as inhibitors of transcription factor activity

Leung, Chung-Hang, He, Hong-Zhang, Liu, Li-Juan, Wang, Modi, Chan, Daniel Shiu-Hin, Ma, Dik-Lung

Journal:

Coordination Chemistry Reviews

Year:

2013

Language:

english

File:

PDF, 887 KB

english, 2013

39

A parallel G-quadruplex-selective luminescent probe for the detection of nanomolar calcium(II) ion

He, Hong-Zhang, Wang, Modi, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Lin, Xuexia, Lin, Jin-Ming, Ma, Dik-Lung

Journal:

Year:

2013

Language:

english

File:

PDF, 926 KB

english, 2013

40

A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3′–5′ proofreading activity

Leung, Ka-Ho, He, Hong-Zhang, Zhong, Hai-Jing, Lu, Lihua, Chan, Daniel Shiu-Hin, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2013

Language:

english

File:

PDF, 645 KB

english, 2013

41

Bioactive iridium and rhodium complexes as therapeutic agents

Leung, Chung-Hang, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Ma, Dik-Lung

Journal:

Coordination Chemistry Reviews

Year:

2013

Language:

english

File:

PDF, 1.18 MB

english, 2013

42

Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme

Zhong, Hai-Jing, Liu, Li-Juan, Chan, Daniel Shiu-Hin, Wang, Hui-Min, Chan, Philip Wai Hong, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2014

Language:

english

File:

PDF, 591 KB

english, 2014

43

Detection of 3′→5′ exonuclease activity using a metal-based luminescent switch-on probe

He, Hong-Zhang, Chan, Weng-I, Mak, Tsun-Yin, Liu, Li-Juan, Wang, Modi, Chan, Daniel Shiu-Hin, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Year:

2013

Language:

english

File:

PDF, 952 KB

english, 2013

44

An oligonucleotide-based switch-on luminescent probe for the detection of kanamycin in aqueous solution

Leung, Ka-Ho, He, Hong-Zhang, Chan, Daniel Shiu-Hin, Fu, Wai-Chung, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

Sensors and Actuators B: Chemical

Year:

2013

Language:

english

File:

PDF, 502 KB

english, 2013

45

A label-free G-quadruplex-based luminescent switch-on assay for the selective detection of histidine

He, Hong-Zhang, Wang, Modi, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Qiu, Jian-Wen, Ma, Dik-Lung

Journal:

Year:

2013

Language:

english

File:

PDF, 1.05 MB

english, 2013

46

Antagonizing STAT3 Dimerization with a Rhodium(III) Complex

Ma, Dik-Lung, Liu, Li-Juan, Leung, Ka-Ho, Chen, Yen-Ting, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Wang, Hui-Min David, Leung, Chung-Hang

Journal:

Angewandte Chemie International Edition

Year:

2014

Language:

english

File:

PDF, 1.30 MB

english, 2014

47

Label-Free Luminescent Switch-on Detection of Endonuclease IV Activity Using a G-Quadruplex-Selective Iridium(III) Complex

Leung, Ka-Ho, He, Hong-Zhang, Wang, Wei, Zhong, Hai-Jing, Chan, Daniel Shiu-Hin, Leung, Chung-Hang, Ma, Dik-Lung

Journal:

ACS Applied Materials & Interfaces

Year:

2013

Language:

english

File:

PDF, 704 KB

english, 2013

48

A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo

Liu, Li-Juan, Lin, Sheng, Chan, Daniel Shiu-Hin, Vong, Chi Teng, Hoi, Pui Man, Wong, Chun-Yuen, Ma, Dik-Lung, Leung, Chung-Hang

Journal:

Journal of Inorganic Biochemistry

Year:

2014

Language:

english

File:

PDF, 595 KB

english, 2014

49

Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-based logic gate

Ma, Dik-Lung, Kwan, Maria Hiu-Tung, Chan, Daniel Shiu-Hin, Lee, Paul, Yang, Hui, Ma, Victor Pui-Yan, Bai, Li-Ping, Jiang, Zhi-Hong, Leung, Chung-Hang

Journal:

The Analyst (Royal Society of Chemistry)

Year:

2011

Language:

english

File:

PDF, 341 KB

english, 2011

50

A natural product-like inhibitor of NEDD8-activating enzyme

Leung, Chung-Hang, Chan, Daniel Shiu-Hin, Yang, Hui, Abagyan, Ruben, Lee, Simon Ming-Yuen, Zhu, Guo-Yuan, Fong, Wang-Fun, Ma, Dik-Lung

Journal:

Chemical Communications

Year:

2011

Language:

english

File:

PDF, 5.99 MB

english, 2011